Zero-Day Vulnerability Response: What to Do in the First 72 Hours

Exploits don’t wait—and neither can your response to a Zero-Day Vulnerability

A zero-day vulnerability can spread before you even know it exists. In 2018, the average time between a vulnerability disclosure and active exploitation was 63 days. By 2023, that window had shrunk to just 5 days. Even more concerning: 70% of exploited vulnerabilities last year were zero-days—attacked before a patch was even available (Google/Mandiant).

The days of waiting for a patch are over. Your team needs a bulletproof 72-hour zero-day vulnerability plan to contain risk before it spreads. One missed system is all it takes to launch ransomware, steal data, or trigger regulatory fallout.

This guide walks through how to respond with speed, visibility, and control—so you’re ready when the next critical CVE hits.

The 72-Hour Response Framework for Zero-Day Vulnerabilities

When a zero-day vulnerability drops, the clock starts ticking. What your team does in the first 72 hours determines whether you contain the threat—or scramble to recover.

This four-phase framework is built to help IT and security teams respond quickly and effectively, even when no patch is available.

  1. Hour 0–6: Assess & Prioritize
  2. Hour 6–24: Harden Systems
  3. Hour 24–48: Remediate Efficiently
  4. Hour 48–72: Validate & Report

Hour 0–6: Assess & Prioritize

The moment a critical zero-day vulnerability is disclosed, clarity is your most valuable asset. This first window isn’t about patching. It’s about quickly understanding the scope, urgency, and impact across your environment.

Key actions to take:

  • Identify affected systems. Use authoritative data sources like the CISA KEV, NIST NVD, and tools like Tenable to determine whether the CVE applies to your OS, software, or configurations.
  • Map exposure. Cross-reference endpoints by OS version, installed applications, and business function. Focus first on internet-facing assets and high-value targets.
  • Group by risk. Prioritize endpoints based on criticality, exposure level, and role in your environment (e.g., production vs. development).
  • Communicate internally. Coordinate across security, IT, and operations teams to align on priorities, define immediate next steps, and clarify what “ready” means for each group.

💡 Pro Tip: Many teams fall behind here due to fragmented visibility. Automating triage with real-time asset inventory and integrated threat intelligence dramatically reduce response time during a critical response window.

 

Hour 6–24: Harden Systems

Once you’ve identified which systems are exposed, the next critical step is to reduce the attack surface before a patch is available. This phase buys time by making systems harder to exploit while you prepare for full remediation.

Key actions to take:

  • Apply baseline security configurations. Use automated tools to enforce consistent firewall rules, user privilege limits, service restrictions, and encryption settings across all endpoints.
  • Apply vendor-recommended workarounds. When no patch is available, follow any published mitigations like disabling vulnerable features or editing configurations, to reduce exploitability. If none exist, assess whether temporary controls (e.g., service restrictions or isolation) can reduce risk.
  • Lock down exposed endpoints. Disconnect or restrict network access to vulnerable systems to prevent attackers from using them to reach others.
  • Disable or restrict risky ports and protocols. Especially for externally facing endpoints or services.
  • Set compensating controls. These can include application allow listing (only permitting trusted software to run), host-based intrusion prevention, or runtime restrictions.
  • Coordinate with impacted teams. Notify system owners or users in advance about upcoming hardening actions—what’s changing, when, and why.

💡 Pro Tip: This phase is often overlooked, but it’s your biggest leverage point when a patch isn’t yet available. Even temporary hardening can block real-world exploitation attempts.

 

Hour 24–48: Remediate Efficiently

Once a patch is released, or a workaround is validated, it’s time to act fast. This phase is about deploying fixes quickly and consistently, without disrupting business operations. A successful response here closes the window of exposure and lays the foundation for audit-proof documentation.

Key actions to take:

  • Deploy OS and third-party patches. Target the most critical and exposed systems first, then work outward to lower-priority assets.
  • Coordinate reboot timing. Suppress or schedule reboots based on operational needs to minimize user disruption while ensuring updates are applied.
  • Run pre- and post-scripts. Back up configurations before patching, then verify patch success and re-enable any temporarily disabled services.
  • Ensure logging and traceability. Make sure every action (installations, reboots, script outcomes) is logged and accessible for reporting.

💡 Pro Tip: Patching isn’t just about speed. It’s about coverage, timing, and documented proof. If you can’t prove what was fixed and when, you’re still exposed in the eyes of auditors and leadership.

 

Hour 48–72: Validate & Report

You’ve patched, hardened, and applied controls—but your response isn’t complete until you can prove it worked. This phase is about confirming coverage, detecting drift, and delivering audit-ready evidence for internal stakeholders, auditors, or regulators.

Key actions to take:

  • Confirm remediation status. Verify that all intended patches were successfully deployed, and workarounds or configurations are still in place.
  • Monitor for drift. Check that hardened settings haven’t reverted or been bypassed during or after patching.
  • Export compliance reports. Generate summaries that include patch versions, config states, timing, and system coverage.
  • Re-enable business-critical services. Carefully restore access or functionality that may have been restricted earlier, using a controlled process.
  • Close the loop with stakeholders. Provide clear documentation of what was done, what worked, and what may still need attention.

💡 Pro Tip: If you can’t demonstrate what was fixed, or where gaps remain, your risk doesn’t just stay internal. It shows up in audits, board reviews, and incident postmortems.

The Cost of an Incomplete Response

Even with the right plan, execution is everything. One missed system or partial fix can be all it takes.

Attackers only need a single gap to launch ransomware, steal data, embed persistent access, or extort your organization. And the fallout isn’t just technical—it can trigger HIPAA, GLBA, or SEC violations, lead to regulatory fines, and erode trust with both customers and leadership.

How Bacon Unlimited Supports Every Phase of Your 72-Hour Response

When a zero-day vulnerability drops, time and clarity are everything. Bacon Unlimited helps IT and security teams act fast, automate key actions, and close the visibility and validation gaps that lead to exposure.

Here’s how Bacon maps to the 72-hour plan:

  • Assess & Prioritize: Map CVEs to affected systems in real time using CISA KEV, NIST NVD, and Tenable integrations—all continuously updated and matched against your environment.
  • Harden Systems: Enforce secure configuration states with prewritten hardening steps, restrict risky services, and apply pre-patch controls at scale across all endpoints—Windows, macOS, and Linux.
  • Remediate Efficiently: Deploy OS and third-party patches instantly across Windows, macOS, and Linux with reboot suppression, custom scripting, and 4-click upgrades—powered by continuous endpoint communication and Tenable-integrated prioritization.
  • Validate & Report: Verify remediation success, detect configuration drift, and export detailed, audit-ready reports—with real-time visibility into patch history, endpoint compliance, and vulnerability status.

Teams that can act in hours—not days—don’t just reduce risk. They lead with confidence, earn trust, and stay ready for whatever comes next.

Ready to Accelerate Your Zero-Day Response?